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  1. Naoyuki Kondo, Akio Ebihara , Heng Ru, Seiki Kuramitsu , Aikichi Iwamoto , Zihe Rao , and Zene Matsuda. Thermus thermophilus-derived protein tags that aid in preparation of insoluble viral proteins Analytical Biochemistry (in press).
  2. Watanabe T, Watanabe S, Shinya K, Kim JH, Hatta M, Kawaoka Y. Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc Natl Acad Sci U S A. 106: 588-592, 2009.
  3. Murakami S, Horimoto T, Le MQ, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y. Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. Journal of Virology (in press).
  4. Murakami S, Iwasa A, Iwatsuki-Horimoto K, Ito M, Kiso M, Kida H, Takada A, Nidom CA, Le MQ, Yamada S, Imai H, Sakai-Tagawa Y, Kawaoka Y, Horimoto T. Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model. Vaccine (in press).
  5. Hou, W, Aoki, C, Yu, L, Wen, X, Xue, Y, Gao, B, Liu, W, Gao, GF, Iwamoto, A, and Kitamura, Y. A recombinant replication-competent hepatitis C virus expressing Azami-Green, a bright green-emitting fluorescent protein, suitable for visualization of infected cells. Biochem Biophys Res Commun. (in press).
  6. Hao L, Sakurai A, Watanabe T, Sorensen E, Nidom CA, Newton MA, Ahlquist P, Kawaoka Y. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 454: 890-893, 2008.
  7. Iwatsuki-Horimoto K, Hatta Y, Hatta M, Muramoto Y, Chen H, Kawaoka Y, Horimoto T. Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Research 135: 161-165, 2008.
  8. Jiao P, Tian G, Li Y, Liu C, Liu W, Deng G, Guan Y, Bu Z, Kawaoka Y, Chen H. A single amino acid subsitutution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. Journal of Virology 82: 1146-1154, 2008.
  9. Zhu Q, Yang H, Deng G, Yu K, Bu Z, Kawaoka Y, Chen H. A naturally occurring deletion in its NS gene contributes to attenuation of an H5N1 swine influenza virus in chickens. Journal of Viroly 82: 220-228, 2008.
  10. Hosoya N, Miura T, Kawana-Tachikawa A, Koibuchi T, Shioda T, Odawara T, Nakamura T, Kitamura Y, Kano M, Kato A, Hasegawa M, Nagai Y, Iwamoto A. Comparison between Sendai virus and adenovirus vectors to transduce HIV-1 genes into human dendritic cells. J Med Virol. 80:373-82, 2008.
  11. Qin, Z, Sun, L, Ma, B, Cui, Z, Zhu, Y, Kitamura, Y, Liu, W. F gene recombination between genotype II and VII Newcastle disease virus. Virus Res. 131: 299-303, 2008.
  12. Hatta M, Hatta Y, Kim JH, Watanabe S, Shinya K, Kawaoka Y. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Patho. 3: 1374-1379, 2007.
  13. Tian, K, Yu, X, Zhao, T, Feng, Y, Cao, Z, Wang, C, Hu, Y, Chen, X, Hu, D, Tian, X, Liu, D, Zhang, S, Deng, X, Ding, Y, Yang, L, Zhang, Y, Xiao, H, Qiao, M, Wang, B, Hou, L, Wang, X, Yang, X, Kang, L, Sun, M, Jin, P, Wang, S, Kitamura, Y, Yan, J, Gao, GF. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE. 2: e526, 2007.
  14. Wichukchinda N, Kitamura Y, Rojanawiwat A, Nakayama EE, Song H, Pathipvanich P, Auwanit W, Sawanpanyalert P, Iwamoto A, Shioda T, Ariyoshi K. The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection. AIDS Res Hum Retroviruses 23: 2686-2692, 2007.
  15. Saito A, Nagasaki M, Oyama M, Kozuka-Hata H, Semba K, Sugano S, Yamamoto T, Miyano S. AYUMS: an algorithm for completely automatic quantitation based on LC-MS/MS proteome data and its application to the analysis of signal transduction. BMC Bioinformatics 8:15, 2007.
  16. Yamamoto H, Kawada M, Tsukamoto T, Takeda A, Igarashi H, Miyazawa M, Naruse T, Yasunami M, Kimura A, Matano T. Vaccine-based long-term stable control of simian-human immunodeficiency virus 89.6PD replication in rhesus macaques. J Gen Virol. 88: 652-659, 2007.
  17. Ariga H, Shimohakamada Y, Tokunaga T, Kikuchi T, Nakata M, Kariyone A, Tamura T, Takatsu K. Instruction of CD4+ T cell fate to T-bet expression and Th1 development by Th1-inducing peptide: roles of T cell receptor-mediated signals. Immunology. 2007.
  18. Ashida, H., Toyotome, T., Nagai, T. and Sasakawa, C. Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol. 63: 680-693, 2007.
  19. Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A. J., Fukui Y. and Sasakawa, C. Shigella IpgB1 promotes bacterial entry through the ELMO?Dock180 machinery. Nat. Cell Biol. 9: 121-128, 2007.
  20. Kunisawa J, Kurashima Y, Gohda M, Higuchi M, Ishikawa I, Miura F, Ogahara I, and Kiyono H. Sphingosine 1-phosphate regulates peritoneal B cell trafficking for subsequent intestinal IgA production. Blood 109: 3749-3756, 2007.
  21. Kim N, Kunisawa J, Kweon MN, Eog Ji G, and Kiyono H. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4+ CD45RB high T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin.Immunol. 123: 30-39, 2007.
  22. Kunisawa J, Takahashi I, and Kiyono H. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol. Rev. 215: 136-153, 2007.
  23. Tamagawa H, Hiroi T, Mizushima T, Ito T, Matsuda H, and Kiyono H. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm. Bowel Dis. 13: 547-556, 2007.
  24. Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, HorimotoT, Shinya K, Sawada T, Kiso M Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y. Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444: 378-382, 2006.
  25. Chen H, Li Y, Li Z, Shi J, Shinya K, Deng G, Qi Q, Tian G, Fan S, Zhao H, Sun Y, Kawaoka Y. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. Journal of Virology 80:5976-5983, 2006.
  26. Koga, I., Odawara, T., Matsuda, M., Goto, M., Nakamura, T., and Iwamoto, A. Analysis of HIV-1 sequences before and after co-infecting syphilis. Microbes and Infection. 14: 167-174, 2006.
  27. Miyauchi K, Komano J, Myint L, Futahashi Y, Urano E, Matsuda Z, Chiba T, Miura H, Sugiura W, Yamamoto N. Rapid propagation of low-fitness drug-resistant mutants of human virus type 1 by a streptococcal metabolite sparsomycin. Antivir Chem Chemother. 14: 167-174, 2006.
  28. Miyauchi K, Curran R, Matthews E, Komano J, Hoshino T, Engelman DM, Matsuda Z. Mutations of Conserved Glycine Residues within the Membrane- Spanning Domain of Human Immunodeficiency Virus type 1 gp41 Can Inhibit Membrane Fusion and Incorporation of Env onto Virions. Jpn J Infect Dis. 59: 77-84, 2006.
  29. Horikawa K, Takatsu K. Interleukin-5 regulates genes involved in B cell terminal maturation. Immunology 118: 497-508, 2006.
  30. Kikuchi T, Uehara S, Ariga H, Tokunaga T, Kariyone A, Tamura T, Takatsu K. Augmented induction of CD8+ cytotoxic T cell response and antitumor resistance by Th1-inducing peptide. Immunology 117: 47-58, 2006.
  31. Yoshida, S., Handa, Y., Suzuki, T., Ogawa, M. Suzuki, M., Tamai, A., Abe, A., Katayama, E. and Sasakawa, C. Microtubule-Severing Activity of Shigella Is Pivotal for Intercellular Spreading. Science 314: 985-989, 2006.
  32. Suzuki, T., Yoshikawa, Y., Ashida, H., Iwai, H., Toyotome, T., Matsui, H. and Sasakawa, C. High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. J. Immunol. 177: 4709-4717, 2006.
  33. Ogawa, M. and Sasakawa, C. Shigella and Autophagy. Autophagy 2: 171-174, 2006.
  34. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, and Kiyono H. Uniqueness of lymphoid chemokine requirement for the initiation and maturation of NALT organogenesis. J. Immunol. 177: 4276-4280, 2006.
  35. Nochi T, and Kiyono H. Innate immunity in the mucosal immune system. Curr. Pharm. Des. 12: 4203-4213, 2006.

The Institute of Medical Science, The University of Tokyo