成果発表(全体)成果発表(全体)

論文発表(全体)

2017

  1. Ui H, Yamayoshi S, Uraki R, Kiso M, Oishi K, Murakami S, Mimori S, Kawaoka Y. Evaluation of seasonal influenza vaccines for H1N1pdm09 and type B viruses based on a replication-incompetent PB2-KO virus. Vaccine 35: 1892-1897, 2017. (APR 2017)
  2. Yamayoshi S, Uraki R, Ito M, Kiso M, Nakatsu S, Yasuhara A, Oishi K, Sasaki T, Ikuta K, Kawaoka Y. A Broadly reactive human anti-hemagglutinin stem monoclonal antibody that inhibits influenza A virus particle release. EBioMedicine 17: 182-191, 2017. (MAR 2017)
  3. Zhao D, Liang L, Wang S, Nakao T, Li Y, Liu L, Guan Y, Fukuyama S, Bu Z, Kawaoka Y, Chen H. Glycosylation of the HA protein of H5N1 influenza virus increases its virulence in mice by exacerbating the host immune response. J Virol 91: e02215-02216, 2017. (MAR 2017)
  4. Nakayama M, Itoh Y, Shichinohe S, Nakabayashi R, Ishigaki H, Sakoda Y, Le QM, Kawaoka Y, Kida H, Ogasawara K. Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus. Vaccine 35: 1008-1017, 2017. (FEB 2017)
  5. Kobayashi R, Kato A, Sagara H, Watanabe M, Maruzuru Y, Koyanagi N, Arii J, Kawaguchi Y. Herpes simplex virus 1 small capsomere-interacting protein VP26 regulates nucleocapsid maturation. J Virol, in press.
  6. Akkina R, Ellerbrok H, Hall W, Hasegawa H, Kawaguchi Y, Kleanthous H, McSweegan E, Mercer N, Romanowski V, Sawa H, Vahlne A. 2016 international meeting of the global virus network. Antiviral Res 142: 21-29, 2017. (JUN 2017)
  7. Maeda F, Arii J, Hirohata Y, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y. Herpes simplex virus 1 UL34 protein regulates the global architecture of the endoplasmic reticulum in infected cells. J Virol 91: e000271-17, 2017. (JUN 2017)

2016

  1. Arafa A-S, Yamada S, Imai M, Watanabe T, Yamayoshi S, Iwatsuki-Horimoto K, Kiso M, Sakai-Tagawa Y, Ito M, Imamura T, Nakajima N, Takahashi K, Zhao D, Oishi K, Yasuhara A, Macken C, Zhong G, Hanson A, Fan S, Ping J, Hatta M, Lopes T, Suzuki Y, El-Husseiny M, Selim A, Hagag N, Soliman M, Neumann G, Hasegawa H, Kawaoka Y. Risk assessment of recent Egyptian H5N1 influenza viruses. Sci Rep 6:38388, 2016. (DEC 6, 2016)
  2. Ando T, Yamayoshi S, Tomita Y, Watanabe S, Watanabe T, Kawaoka Y. The host protein CLUH participates in the subnuclear transport of influenza virus ribonucleoprotein complexes. Nat Microbiol 1:16062, 2016. (AUG 2016)
  3. Li C, Hatta M, Burke DF, Ping J, Zhang Y, Ozawa M, Taft AS, Das SC, Hanson AP, Song J, Imai M, Wilker PR, Watanabe T, Watanabe S, Ito M, Iwatsuki-Horimoto K, Russell CA, James SL, Skepner E, Maher EA, Neumann G, Klimov A, Kelso A, McCauley J, Wang D, Shu Y, OdagiriT, Tashiro M, Xu X, Wentworth DE, Katz JM, Cox NJ, Smith DJ, Kawaoka Y. Selection of antigenically advanced variants of seasonal influenza viruses. Nat Microbiol 1:16058, 2016. (JUN 2016)
  4. Moncla LH, Zhong G, Nelson CW, Dinis JM, Mutschler J, Hughes AL, Watanabe T, Kawaoka Y, Friedrich TC. Selective bottlenecks shape evolutionary pathways taken during mammalian adaptation of a 1918-like avian influenza virus. Cell Host Microbe 19:169-180, 2016. (FEB 10, 2016)
  5. Katsura H, Fukuyama S, Watanabe S, Ozawa M, Neumann G, Kawaoka Y. Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter protein. Sci Rep 6:19933, 2016. (FEB 5, 2016)
  6. Yang H, Chen Y, Qiao C, He X, Zhou H, Sun Y, Yin H, Meng S, Liu L, Zhang Q, Kong H, Gu C, Li C, Bu Z, Kawaoka Y, Chen H. Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses. Proc Natl Acad Sci USA 113:392-397, 2016. (JAN 2016)
  7. Yamayoshi S, Watanabe M, Goto H, Kawaoka Y. Identification of A Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus. J Virol 90:444-456, 2016. (JAN 2016)
  8. Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue J, Matsuda Z. Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S-mediated membrane fusion using the split protein-based cell-cell fusion assay. Antimicrob Agents Chemother 60:6532-6539, 2016. (DOI:10.1128/AAC.01043-16) (Aug 22, 2016)
  9. J. Arii, K. Shindo, N. Koyanagi, A. Kato and Y. Kawaguchi. Multiple Roles of the Cytoplasmic Domain of Herpes Simplex Virus 1 Envelope Glycoprotein D in Infected Cells. J Virol 90:10170-10181, 2016. (NOV 2016)
  10. S. Oda, J. Arii, N. Koyanagi, A. Kato, and Y. Kawaguchi. Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis. J Virol 90:8754-8767, 2016. (OCT 2016)
  11. N. Maeda, A. Furukawa, K. Kakita, M. Anada, S. Hashimoto, S. Matsunaga, K. Kuroki, T. Ose, A. Kato, J. Arii, Y. Kawaguchi, H. Arase and K. Maenaka. Rapid screening by cell-based fusion assay for identifying novel antivirals of 5 glycoprotein B-mediated herpes simplex virus type 1 infection. Biol. Pharm. Bull 39:1897-1902, 2016. (JUL 2016)
  12. Y. Maruzuru, N. Koyanagi, N. Takemura, S. Uematsu, D. Matsubara, Y. Suzuki, J. Arii, A. Kato, and Y. Kawaguchi. p53 is a Host Cell Regulator during Herpes Simplex Encephalitis. J Virol 90: 6738-6745, 2016. (AUG 2016)
  13. A. Kato, T. Ando, S. Oda, M. Watanabe, N. Koyanagi, J. Arii and Y. Kawaguchi. Roles of Us8A and its phosphorylation mediated by Us3 in herpes simplex virus 1 pathogenesis. J Virol 90:5622-5635, 2016. (JUN 2016)
  14. Y. Sato, A. Kato, Y. Maruzuru, M. Oyama, H. Kozuka-Hata, J. Arii and Y. Kawaguchi. (2016) Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication. J. Virol 90:3173-3186, 2016. (MAR 2016)
  15. Y. Sato, A. Kato, J. Arii, N. Koyanagi, H. Kozuka-Hata, M. Oyama and Y. Kawaguchi. (2016) Ubiquitin-Specific Protease 9X in Host Cells Interacts with Herpes Simplex Virus 1 ICP0. J. Vet. Med. Sci. 78:405-410, 2016. (MAR 2016)
  16. Shindo K, Kato A, Koyanagi N, Sagara H, Arii J, and Kawaguchi Y. Characterization of a herpes simplex virus 1 (HSV-1) chimera in which the Us3 protein kinase gene is replaced with the HSV-2 Us3 gene. J Virol 90:457-473, 2016. (JAN 2016)

2015

  1. Hanson A, Imai M, Hatta M, McBride R, Imai H, Taft A, Zhong G, Watanabe T, Suzuki Y, Neumann G, Paulson JC, Kawaoka Y. Identification of Stabilizing Mutations in an H5 HA Influenza Virus Protein. J Virol 90:2981-2992, 2015. (DEC 30, 2015)
  2. Zhao D, Fukuyama S, Sakai-Tagawa Y, Takashita E, Shoemaker JE, Kawaoka Y. C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection. Antimicrob Agents Chemother 60:1902-1906, 2015. (DEC 28, 2015)
  3. Uraki R, Piao Z, Akeda Y, Iwatsuki-Horimoto K, Kiso M, Ozawa M, Oishi K, Kawaoka Y. A bivalent vaccine based on a PB2-knockout influenza virus protects mice from secondary pneumococcal pneumonia. J Infect Dis 212:1939-1948, 2015. (DEC 15, 2015)
  4. Uraki R, Piao Z, Akeda Y, Iwatsuki-Horimoto K, Kiso M, Ozawa M, Oishi K, Kawaoka Y. A bivalent vaccine based on a PB2-knockout influenza virus protects mice from secondary pneumococcal pneumonia. J Infect Dis 212(12):1939-1948, 2015. (DEC 15, 2015)
  5. Forero A, Tisoncik-Go J, Watanabe T, Zhong G, Hatta M, Tchitchek N, Selinger C, Chang J, Barker K, Morrison J, Berndt JD, Moon RT, Josset L, Kawaoka Y, Katze MG. The 1918 PB2 protein enhances virulence through the disruption of inflammatory and Wnt-mediated signaling in mice. J Virol 90:2240-2253, 2015. (DEC 09, 2015)
  6. Zhao D, Fukuyama S, Yamada S, Lopes TJ, Maemura T, Katsura H, Ozawa M, Watanabe S, Neumann G, Kawaoka Y. Molecular determinants of virulence and stability of a reporter-expressing H5N1 influenza A virus. J Virol 89:11337-11346, 2015. (NOV 2015)
  7. Ping J, Lopes T.J.S, Nidom CA, Ghedin E, Macken CA, Fitch A, Imai M, Maher EA, Neumann G, Kawaoka Y. Development of high-yield influenza A virus vaccine viruses. Nat Commun 6:8148, 2015. (SEP 2015)
  8. Oishi K, Yamayoshi S, Kawaoka Y. Mapping of a region of the PA-X protein of influenza A virus that is important for its shut-off activity. J Virol 89:8661-8665, 2015. (AUG 2015)
  9. Shoemaker JE, Fukuyama S, Eisfeld AJ, Zhao D, Kawakami E, Sakabe S, Maemura T, Gorai T, Katsura H, Muramoto Y, Watanabe S, Watanabe T, Fuji K, Matsuoka Y, Kitano H, Kawaoka Y. An ultrasensitive mechanism regulates influenza virus-induced inflammation. PLoS Pathog e1004856, 2015. (JUN 2015)
  10. Taft AS, Ozawa M, Fitch A, Depasse JV, Halfmann PJ, Hill-Batorski L, Hatta M, Friedrich TC, Lopes TJS, Maher EA, Ghedin E, Macken CA, Neumann B, Kawaoka Y. Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus. Nat Commun 6:7491, 2015. (JUN 2015)
  11. Yamaji R, Yamada S, Le MQ, Li C, Chen H, Qurnianingsih E, Nidom CA, Ito M, Sakai-Tagawa Y, Kawaoka Y. Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells. J Virol 89:3947-3956, 2015. (APR 2015)
  12. Yamaji R, Yamada S, Le MQ, Ito M, Sakai-Tagawa Y, Kawaoka Y. Mammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus. J Virol 89:4117-4125, 2015. (APR 2015)
  13. Fukuyama S, Katsura H, Zhao D, Ozawa M, Ando T, Shoemaker JE, Ishikawa I, Yamada S, Neumann G, Watanabe S, Kitano H, Kawaoka Y. Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies. Nat Commun, 6:6600, 2015. (MAR 2015)
  14. Yamayoshi S, Fukuyama S, Yamada S, Zhao D, Murakami S, Uraki R, Watanabe T, Tomita Y, Neumann G, Kawaoka Y. Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts. Sci Rep 5:8039, 2015. (JAN 27, 2015)
  15. Nakane S, Iwamoto A, Matsuda Z. The V4 and V5 variable loops of HIV-1 envelope glycoprotein are tolerant to insertion of green fluorescent protein and are useful targets for labeling. J Biol Chem 290(24):15279-91, 2015. (JUN 12, 2015)
  16. Nakane S, Matsuda Z. Dual split protein (DSP) assay to monitor cell-cell membrane fusion. Methods Mol Biol 1313:229-36, 2015. (doi: 10.1007/978-1-4939-2703-6_17.) (JUN 2015)
  17. Saw WT, Matsuda Z, Eisenberg RJ, Cohen GH, Atanasiu D. Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins. Methods pii:S1046-2023(15)00227-3, 2015. (doi:10.1016/j.ymeth.2015.05.021) (MAY 26, 2015)
  18. Matsuda Z. Recent advance in the structural analysis of HIV-1 envelope protein. Sci China Life Sci May;58(5):420-424, 2015.(MAY 2015)
  19. Liu C, Zhao Y, He W, Wang W, Chen Y, Zhang S, Ma Y, Gohda J, Ishida T, Walter TS, Owens RJ, Stuart DI, Ren J, Gao B. A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis. Sci Rep 5:14150, 2015.(SEP 28, 2015)
  20. Gu L, Han Y, Li Y, Zhu T, Song X, Huang H, Yang F, Guan S, Xie J, Gohda J, Hosoya N, Kawana-Tachikawa A, Liu W, Gao GF, Iwamoto A, Li T, Ishida T. Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China. PLoS ONE 10(8):e0134539, 2015. (AUG 2015)
  21. Li Y, Gu L, Han Y, Xie J, Wang H, Lv W, Song X, Li Y, Iwamoto A, Ishida T, Li T. HIV-1 subtype B/B' and baseline drug resistance mutation are associated with virologic failure: a multicenter cohort study in China. J Acquir Immune Defic Syndr 68(3):289-97, 2015. (MAR 2015)
  22. Gohda J, Ma Y, Huang Y, Zhang Y, Gu L, Han Y, Li T, Gao B, Gao GF, Inoue J-i, Iwamoto A, Ishida T. HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro. Retrovirology 12:12, 2015. (FEB 7, 2015)
  23. Matsuda Y, Kobayashi-Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep 5:7701, 2015.(JAN 9, 2015)
  24. Nakayama-Hosoya K, Ishida T, Youngblood B, Nakamura H, Hosoya N, Koga M, Koibuchi T, Iwamoto A, Kawana-Tachikawa A. Epigenetic repression of interleukin 2 expression in senescent CD4+ T cells during chronic HIV type 1 infection. J Infect Dis 211:28-39, 2015. (JAN 1, 2015)
  25. Liu Z, Kato A, Oyama M, Kozuka-Hata H, Arii J, Kawaguchi Y. Role of host cell p32 in herpes simplex virus 1 de-envelopment during viral nuclear egress. J Virol 89(17):8982-8998, 2015. (SEP 2015)
  26. Hirohata Y, Arii J, Liu Z, Shindo K, Oyama M, Kozuka-Hata H, Sagara H, Kato A, Kawaguchi Y. Herpes simplex virus 1 recruits CD98 heavy chain and β1 integrin to the nuclear membrane for viral de-envelopment. J Virol 89(15):7799-7812, 2015. (AUG 2015)
  27. Arii J, Hirohata Y, Kato A and Kawaguchi Y. Nonmuscle myosin heavy chain IIB mediates herpes simplex virus 1 entry. J Virol 89(3):1879-1888, 2015. (FEB 2015)
  28. Kobayashi R, Kato A, Oda S, Koyanagi N, Oyama M, Kozuka-Hata H, Arii J,Kawaguchi Y. The function of the herpes simplex virus 1 small capsid protein VP26 is regulated by phosphorylation at a specific site. J Virol 89(11): 6141-6147, 2015. (JUN 2015)
  29. Hirohata Y, Kato A, Oyama M, Kozuka-Hata H, Koyanagi N, Arii J, Kawaguchi Y. Interactome analysis of herpes simplex virus 1 envelope glycoprotein H. Microbiol Immunol 59(6):331-337, 2015. (JUN 2015)
  30. Kato A, Arii J, Koyanagi Y, Kawaguchi Y. Phosphorylation of herpes simplex virus 1 dUTPase regulates viral virulence and genome integrity by compensating for low cellular dUTPase activity in the central nervous system. J Virol 89(1):241-248, 2015. (JAN 2015)

2014

  1. Fan S, Hatta M, Kim JH, Le MQ, Neumann G, Kawaoka Y. Amino Acid Changes in the Influenza A Virus PA Protein That Attenuate Avian H5N1 Viruses in Mammals. J Virol 88:13737-13746, 2014 (DEC 2014).
  2. Fan S, Hatta M, Kim JH, Halfmann P, Imai M, Macken CA, Le MQ, Nguyen T, Neumann G, Kawaoka Y. Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts. Nat Commun 5:5021, 2014 (OCT 2014).
  3. Sakai-Tagawa Y, Ozawa M, Yamada S, Uchida Y, Saito T, Takahashi K, Sugaya N, Tashiro M, Kawaoka Y. Detection sensitivity of influenza rapid diagnostic tests. Microbiol Immunol 58:600-606, 2014 (OCT 2014).
  4. Uraki R, Das SC, Hatta M, Kiso M, Iwatsuki-Horimoto K, Ozawa M, Coban C, Ishii KJ, Kawaoka Y. Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine. Vaccine 32:5295-300, 2014 (SEP 15, 2014)
  5. Muramoto Y, Shoemaker JE, Le MQ, Itoh Y, Tamura D, Sakai-Tagawa Y, Imai H, Uraki R, Takano R, Kawakami E, Ito M, Okamoto K, Ishigaki H, Mimuro H, Sasakawa C, Matsuoka Y, Noda T, Fukuyama S, Ogasawara K, Kitano H, Kawaoka Y. Disease Severity Is Associated with Differential Gene Expression at the Early and Late Phases of Infection in Nonhuman Primates Infected with Different H5N1 Highly Pathogenic Avian Influenza Viruses. J Virol 88:8981-8997, 2014 (AUG 2014).
  6. Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K, Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Quynh Mai L, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A. Protective efficacy of passive immunization with monoclonal antibodies in animal models of H5N1 highly pathogenic avian influenza virus infection. PLoS Pathog. 10:e1004192, 2014 (JUN 2014).
  7. Watanabe T, Zhong G, Russell CA, Nakajima N, Hatta M, Hanson A, McBride R, Burke DF, Takahashi K, Fukuyama S, Tomita Y, Maher A, Watanabe S, Imai M, Neumann G, Hasegawa H, Paulson JC, Smith DJ, Kawaoka Y. Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential. Cell Host&Microbe 15:692-705, 2014 (JUN 11, 2014).
  8. Liu Z, Kato A, Shindo K, Noda T, Sagara H, Kawaoka Y, Arii J, Kawaguchi Y. Herpes simplex virus 1 UL47 interacts with viral nuclear egress factors UL31, UL34 and Us3, and regulates viral nuclear egress. J Virol 88:4657-4667, 2014.
  9. Li, W., Wen, C., Bai, H., Wang, X., Zhang, X., Huang, L., Yang, X., Iwamoto, A., and Liu, H. JNK signaling pathway is involved in piperlongumine-mediated apoptosis in human colorectal cancer HCT116 cells. Oncology Letters, in press, 2015.
  10. Lu, B., Wang, C., Zhang, J., Kuiper, R.P., Song, M., Zhang, X., MD, Song, S., van Kessel, Ad Geurts., Iwamoto, A., Wang, J., and Liu, H. Perivascular epithelioid cell tumor of gastrointestinal tract: case report and review of the literature. Medicine 94(3):e393, 2015 (JAN 2015)
  11. Gu, L., Kawana-Tachikawa, A., Shiino, T. , Nakamura, H., Koga, M., Kikuchi, T., Adachi, E., Koibuchi, T., Ishida, T. Gao, G.F., Matsushita, M., Sugiura, W., Iwamoto, A. and Hosoya, N. Development and customization of a color-coded microbeads-based assay for drug resistance in HIV-1 reverse transcriptase. PLoS ONE, 9(10):e109823, 2014 (OCT 14, 2014).
  12. Wang, Q., Qi, J., Yuan, Y., Xuan, Y., Han, P., Wan, Y., Ji, W., Li, Y., Wu, Y., Wang, J., Iwamoto, A., Woo, P.C.Y., Yuen, K-Y., Yan, J., Lu, G., and Gao, G.F. Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26. Cell Host&Microbe 16: 1-10, 2014 (SEP 10, 2014).
  13. Wang H, Li X, Nakane S, Liu S, Ishikawa H, Iwamoto A, Matsuda Z. Co-expression of foreign proteins tethered to HIV-1 envelope glycoprotein on the cell surface by introducing an intervening second membrane-spanning domain. PLoS ONE 9(5):e96790, 2014 (MAY 7, 2014).
  14. Han C, Kawana-Tachikawa A, Shimizu A, Zhu D, Nakamura H, Adachi E, Kikuchi T, Koga M, Koibuchi T, Gao GF, Sato Y, Yamagata A, Martin E, Fukai S, Brumme ZL, Iwamoto A. Switching and emergence of CTL epitopes in HIV-1 infection. Retrovirology 11:38,2014. doi:10.1186/1742-4690-11-38, 2014 (May 21, 2014).
  15. Ota Y, Hishima T, Mochizuki M, Kodama Y, Moritani S, Oyaizu N, Mine S, Ajisawa A, Tanuma J, Uehira T, Hagiwara S, Yajima K, Koizumi Y, Shirasaka T, Kojima Y, Nagai H, Yokomaku Y, Shiozawa Y, Koibuchi T, Iwamoto A, Oka S, Hasegawa H, Okada S, Katano H. Classification of AIDS- related lymphoma cases between 1987 and 2012 in Japan based on the WHO Classification of Lymphomas, fourth edition. Cancer Med. 3(1):143-53, 2014. doi: 10.1002/cam4.178.(FEB 2014).
  16. Li Y, Han Y, Xie J, Gu L, Li W, Wang H, Li W, Song X, Li Y, Routy JP, Ishida T, Iwamoto A and Li T. CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission. AIDS, 28, 521-530, FEB 20 2014
  17. Kogai H, Kikuchi S, Obana T, Tsuboi Y, Maruyama T, Sakurai-Yageta M, Asamura H, Kanai Y, Murakami Y. Promoter methylation of the CADM1 and 4.1B genes occurs independently of the EGFR or the KRAS2 mutation in non-small cell lung cancer. Journal of Cancer Therapy, 6, 273-285, 2015 (MAR 2015).
  18. Sakurai-Yageta M, Maruyama T, Suzuki T, Ichikawa K, Murakami Y. Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-fitting. PLoS ONE, 10(3):e0116637,2015 (MAR 17 2015).
  19. Matsubara D, Murakami Y, Niki T. Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer. Pathology International, 64(11):560-568, 2014. (doi: 10.1111/pin.12214) (NOV 2014).
  20. Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y. Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition. Human Pathology 45, 1397-1405, 2014. (doi: 10.1016/j.humpath.2014.02.013.) (JUL 2014).
  21. Ebihara Y, Iwai M, Akashi K, Ito T, Omura G, Saito Y, Yoshida M, Ando M, Asakage T, Yamasoba T, Murakami Y. High incidence of null-type mutations of the TP53 gene in Japanese patients with head and neck squamous cell carcinoma. Journal of Cancer Therapy 5, 664-671, 2014. (doi.org/10.4236/jct.2014.57075) .(JUN 2014).
  22. Wang F, Akashi K, Murakami Y, Inoue Y, Furuta T, Yamada H, Ohtomo K, Kiryu S. Detection of lung tumors in mice using a 1-Tesla compact magnetic resonance imaging system. PLoS One 9, e94945, 2014. (doi: 10.1371/journal.pone.0094945. (APR 17, 2014).
  23. Cortez VS, Cervantes-Barragan L, Song C, Gilfillan S, McDonald KG, Edelson BT, Murakami Y, Newberry RD, Sibley LD, Colonna M. CRTAM controls residency of gut CD4+CD8+T cells in the steady state and maintenance of gut CD4 TH17 during parasitic infection. J Exp Med 211, 623-633, 2014. (DOI: 10.1084/jem.20130904.) (APR 7, 2014).
  24. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol, 88(23), 13699-13708, 2014 (DEC 2014).
  25. Fujii H, Kato A, Mugitani M, Kashima Y, Oyama M, Kozuka-Hata H, Arii J, Kawaguchi Y. The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation. J Virol 88: 10624-10634, 2014 (SEP 2014).
  26. Maruzuru Y, Shindo K, Liu Z, Oyama M, Kozuka-Hata H, Arii J, Kato A, Kawaguchi Y. The Role of Herpes Simplex Virus 1 Immediate-Early Protein ICP22 in Viral Nuclear Egress. J Virol 88: 7445-7454, 2014 (JUL 2014).
  27. Kato A, Hirohata Y, Arii J, Kawaguchi Y. Phosphorylation of Herpes Simplex Virus 1 dUTPase Upregulated Viral dUTPase Activity to Compensate for Low Cellular dUTPase Activity for Efficient Viral Replication. J Virol 88: 7776-7785, 2014 (JUL 2014).
  28. Akiyama, T., Shiraishi, T., Qin, J., Konno, H., Akiya Ohashi, H., Miyamoto-Sato, E., Yanagawa, H., Yong, W., Shou, W. and Inoue, J. Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN. PLoS ONE 9(5):e95992, 2014. (doi:10.1371/journal.pone.0095992.) (MAY 1, 2014).
  29. Ohto U, Shibata T, Tanji H, Ishida H, Krayukhina E, Uchiyama S, Miyake K, Shimizu T. Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature 2015. ( doi: 10.1038/nature14138.) (APR 30 2015).
  30. Li X, Saitoh SI, Shibata T, Tanimura N, Fukui R, Miyake K. Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes. Int Immunol 27:83-94, 2015. (doi: 10.1093/intimm/dxu086.) (FEB 2015).
  31. Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K. Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases. Nat Commun 6, 2015. ( doi: 10.1038/ncomms7119.) (FEB 2015).
  32. Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K, Shimizu T. Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat Struct Mol Biol 22:109-15, 2015. ( doi: 10.1038/nsmb.2943.) (FEB 2015).
  33. Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, Miyake K. DNase II-dependent DNA digestion is required for DNA sensing by TLR9. Nat Commun 6:5853, 2015. (doi: 10.1038/ncomms6853.) (JAN 2015).

2013

  1. Neumann G, Macken CA, Kawaoka Y. Identification of amino acid changes that may have been critical for the genesis of A(H7N9) influenza viruses. J Virol 88:4877-4896, 2014.
  2. Yamayoshi S, Yamada S, Fukuyama S, Murakami S, Zhao D, Uraki R, Watanabe T, Tomita Y, Macken C, Neumann G, Kawaoka Y. Virulence-affecting amino acid changes in the PA protein of H7N9 influenza A viruses. J Virol 88:3127-3134, 2014.
  3. Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N, Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Ito M, Kawaoka Y, Kida H, Ogasawara K. Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine. PLoS One 8:e82740, 2013.
  4. Wilker PR, Dinis JM, Starrett G, Imai M, Hatta M, Nelson CW, O’Connor DH, Hughes AL, Neumann G, Kawaoka Y, Friedrich TC. Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses. Nat Commun 4:2636, 2013.
  5. Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y. Transmission of influenza A/H5N1 viruses in mammals. Virus Res 178:15-20, 2013.
  6. Takahashi T, Song J, Suzuki T, Kawaoka Y. Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. PLoS One 8:e64439, 2013.
  7. Deng G, Tan D, Shi J, Cui P, Jiang Y, Liu L, Tian G, Kawaoka Y, Li C, Chen H. Complex reassortment of multiple subtypes of avian influenza viruses in domestic ducks at the Dongting Lake region of China. J Virol 87:9452-9462, 2013.
  8. Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y, Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y. Characterization of H7N9 influenza A viruses isolated from humans. Nature 501:551-555, 2013.
  9. Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, Imai Y. The lipid mediator protectin d1 inhibits influenza virus replication and improves severe influenza. Cell 153:112-125, 2013.
  10. Kiso M, Takano R, Sakabe S, Katsura H, Shinya K, Uraki R, Watanabe S, Saito H, Toba M, Kohda N, Kawaoka Y. Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus. Sci Rep 3:1563, 2013.
  11. Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M. Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill 18(15), 2013.
  12. Uraki R, Kiso M, Iwatsuki-Horimoto K, Fukuyama S, Takashita E, Ozawa M, Kawaoka Y. A novel bivalent vaccine based on a PB2-knockout influenza virus protects mice from pandemic H1N1 and highly pathogenic H5N1 virus challenges. J Virol 87:7874-7881, 2013.
  13. Ozawa M, Shimojima M, Goto H, Watanabe S, Hatta Y, Kiso M, Furuta Y, Horimoto T, Peters NR, Hoffmann FM, Kawaoka Y. A cell-based screening system for influenza A viral RNA transcription/replication inhibitors. Sci Rep 3:1106, 2013.
  14. Fan S, Macken CA, Li C, Ozawa M, Goto H, Iswahyudi, Nidom CA, Chen H, Neumann G, Kawaoka Y. Synergistic effect of the PDZ and the p85β-binding domains of the NS1 protein in virulence of an avian H5N1 influenza A virus. J Virol 87:4861-4871, 2013.
  15. Watanabe T, Tisoncik-Go J, Tchitchek N, Watanabe S, Benecke AG, Katze MG, Kawaoka Y. 1918 HA and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice. J Virol 87:5239-5254, 2013.
  16. Uraki R, Kiso M, Shinya K, Goto H, Takano R, Iwatsuki-Horimoto K, Takahashi K, Daniels RS, Hungnes O, Watanabe T, Kawaoka Y. Virulence determinants of pandemic A(H1N1)2009 virus in a mouse model. J Virol 87:2226-2233, 2013.
  17. Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y. Identification of novel influenza A virus proteins translated from PA mRNA. J Virol 87:2344-2362, 2013.
  18. Sakabe S, Takano R, Nagamura-Inoue T, Yamashita N, Nidom CA, Quynh Le MT, Iwatsuki-Horimoto K, Kawaoka Y. Differences in cytokine production in human macrophages and in virulence in mice are attributable to the acidic polymerase protein of highly pathogenic influenza A virus subtype H5N1. J Infect Dis 207: 262-271, 2013.
  19. Takano R, Kiso M, Igarashi M, Le QM, Sekijima M, Ito K, Takada A, Kawaoka Y. Molecular mechanisms underlying oseltamivir resistance mediated by an I117V substitution in the NA of H5N1 avian influenza viruses. J Infect Dis 207: 89-97, 2013.
  20. Shimizu A, Kawana-Tachikawa A, Yamagata A, Han C, Zhu D, Sato Y, Nakamura H, Koibuchi T, Carlson J, Martin E, Brumme CJ, Shi Y, Gao GF, Brumme ZL, Fukai S, Iwamoto A. Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection. Sci Rep 3:3097, 2013. (doi:10.1038/srep03097.)
  21. Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Gotoh H, Zhu D, Nakayama K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and redifferentiation. Cell Stem Cell 12 (1): 114-126, 2013.
  22. Teeranaipong P, Hosoya N, Kawana-Tachikawa A, Fujii T, Koibuchi T, Nakamura H, Koga M, Kondo N, Gao GF, Hoshino H, Matsuda Z, Iwamoto A. Development of a rapid cell-fusion-based phenotypic HIV-1 tropism assay. J Int AIDS Soc 16:18723, 2013.
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  23. Nomura S, Hosoya N, Brumme Z, Brockman M, Kikuchi T, Koga M, Nakamura H, Koibuchi T, Fujii T, Carlson J, Heckerman D, Kawana-Tachikawa A, Iwamoto A, Miura T. Significant reductions in gag-protease mediated HIV-1 replication capacity over the course of the epidemic in Japan. J Virol 87(3):1465-1476, 2013 Feb. (doi: 10.1128/JVI.02122-12. Epub 2012 Nov 14. PubMed PMID:23152532; PubMed Central PMCID: PMC3554148.)
  24. Atanasiu D, Saw WT, Gallagher JR, Hannah BP, Matsuda Z, Whitbeck JC, Cohen GH, Eisenberg RJ. A dual split protein-based fusion assay reveals that mutations to HSV glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteins. J Virol 2013 Aug 14. [Epub ahead of print]
  25. Li Y, Han Y, Xie J, Gu L, Li W, Wang H, Li W, Song X, Li Y, Routy JP, Ishida T, Iwamoto A, Li T. CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission. AIDS, in press.
  26. Suzuki K, Hattori S, Marks K, Ahlenstiel C, Maeda Y, Ishida T, Millington M, Boyd M, Symonds G, Cooper DA, Okada S, Kelleher AD. Promoter targeting shRNA suppresses HIV-1 infection in vivo through transcriptional gene silencing. Mol Ther Nucleic Acids 2:e137, 2013.
  27. Ohsugi T, Ishida T, Shimasaki T, Okada S, Umezawa K. p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein. Carcinogenesis, in press.
  28. Nakano K, Ando T, Yamagishi M, Yokoyama K, Ishida T, Ohsugi T, Tanaka Y, Brighty DW, Watanabe T. Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication. Microbes Infect, in press.
  29. Yamamoto M, Taguchi Y, Ito-Kureha T, Semba K, Yamaguchi N, Inoue J. NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype. Nat Commun 4:2299, 2013. (doi: 10.1038/ncomms3299.)
  30. Yamaguchi N, Oyama M, Kozuka-Hata H, Inoue J. Involvement of A20 in the molecular switch that activates the non-canonical NF-κB pathway. Sci Rep 3: 2568, 2013. (doi:10.1038/srep02568.)
  31. Tanimura N, Saitoh S, Ohto U, Akashi-Takamura S, Fujimoto Y, Fukase K, Shimizu T, Miyake K. The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of TLR4/MD2 complex at the plasma membrane. Int Immunol, 2013. (doi:10.1093/intimm/dxt071.)
  32. Kayagaki N, Wong MT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszynski A, Forsberg LS, Carlson RW, Dixit VM. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341(6151):1246-1249, 2013. (doi:10.1126/science.1240248.)
  33. Miyake K, Onji M. Endocytosis-free DNA sensing by cell surface TLR9 in neutrophils: Rapid defense with autoimmune risks. Eur J Immunol 43:2006-2009, 2013. (doi: 10.1002/eji.201343882.)
  34. Hiratsuka S, Ishibashi S, Tomita T, Watanabe A, Akashi-Takamura S, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y. Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci. Nat Commun 4:1853, 2013. (doi: 10.1038/ncomms2856.)
  35. Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun 4:1949, 2013. (doi:10.1038/ncomms2949.)
  36. Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, Kaneko D, Kumagai Y, You DJ, Carreras J, Uematsu S, Jang MH, Takeuchi O, Kaisho T, Akira S, Miyake K, Tsutsui H, Saito T, Nishimura I, Tsuji NM. Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. Immunity 38(6):1187-1197, 2013. (doi: 10.1016/j.immuni.2013.02.024.)
  37. Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science 339:1426-1429, 2013. (doi: 10.1126/science.1229159.)
  38. Arai S, Maehara N, Iwamura Y, Honda SI, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura KI, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T. Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep 3(4):1187-1198, 2013. (doi: 10.1016/j.celrep.2013.03.006.)
  39. Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M. Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B Cells. J Immunol 190:195-204, 2013.
  40. Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K. Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing. Int Immunol, in press.
  41. Kondo Y, Ikeda K, Tokuda N, Nishitani C, Akashi-Takamura S, Ito Y, Uchikawa M, Kuroki Y, Taguchi R, Miyake K, Zhang Q, Furukawa K, Furukawa K. TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide. Proc Natl Acad Sci U S A, in press.
  42. Yamakawa N, Ohto U, Akashi-Takamura S, Takahashi K, Saitoh SI, Tanimura N, Suganami T, Ogawa Y, Shibata T, Shimizu T, Miyake K. Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A. Int Immunol, in press.
  43. Ito T, Sakurai-Yageta M, Goto A, Murakami Y. Genomic and transcriptional alterations of cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Sciences, in press.
  44. Murakami S, Sakurai-Yageta M, Maruyama T, Murakami Y. Intercellular adhesion of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PLoS One 9:e82894, 2014. (DOI: 10.1371/journal.pone.0082894.)
  45. Mimae T, Hagiyama M, Inoue T, Yoneshige A, Kato T, Okada M, Murakami Y, Ito A. Increased ectodomain shedding of lung-epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema. Thorax 67(3):223-231, 2014. (DOI: 10.1136/thoraxjnl-2013-203867.)
  46. Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T. Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci 104: 266-273, 2013. (doi: 10.1111/cas.12065.)
  47. Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K, Akimitsu N. Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol Cell 53:393-406, 2014.
  48. Liu Z, Kato A, Shindo K, Noda T, Sagara H, Kawaoka Y, Arii J, Kawaguchi Y. Herpes simplex virus 1 UL47 interacts with viral nuclear egress factors UL31, UL34 and Us3, and regulates viral nuclear egress. J Virol 88:4657-4667, 2014.
  49. Koyanagi N, Imai T, Arii J, Kato A, Kawaguchi Y. Roles of herpes simplex virus 1 Us3 in viral neuroinvasiveness. Microbiol Immunol 58:31-37, 2014.
  50. Fujii H, Mugitani M, Koyanagi N, Liu Z, Tsuda S, Arii J, Kato A, Kawaguchi Y. Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence. J Virol 88:2359-2364, 2014.
  51. Kato A, Shindo K, Maruzuru Y, Kawaguchi Y. Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase Us3 dictates viral pathogenicity in the central nervous system but not at the periphery. J Virol 88:2775-2785, 2014.
  52. Kato A, Tsuda S, Liu Z, Kozuka-Hata H, Oyama M, Kawaguchi Y. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells. J Virol 88:655-666, 2014.
  53. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, and Kawaguchi Y. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One 8:e72050, 2013.
  54. Maruzuru Y, Fujii H, Oyama M, Kozuka-Hata H, Kato A and Kawaguchi Y. Roles of p53 in herpes simplex virus 1 replication. J Virol 87:9323-9332, 2013.
  55. Kawaguchi Y. Us3, a multi-functional protein kinase encoded by herpes simplex virus 1: how does it function in vivo? Cornea 32:S22-S27, 2013.
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2012

  1. Takahashi T, Nidom CA, Quynh Le MT, Suzuki T, Kawaoka Y. Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase. FEBS Open Bio 2:261-265, 2012.
  2. Shoemaker JE, Fukuyama S, Eisfeld AJ, Muramoto Y, Watanabe S, Watanabe T, Matsuoka Y, Kitano H, Kawaoka Y. Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs. BMC Syst Biol 6:117, 2012.
  3. Das SC, Hatta M, Wilker PR, Myc A, Hamouda T, Neumann G, Baker JR Jr, Kawaoka Y. Nanoemulsion W(80)5EC improves immune responses upon intranasal delivery of an inactivated pandemic H1N1 influenza vaccine. Vaccine 30:6871-6877, 2012.
  4. Imai M, Watanabe S, Kawaoka Y. The cytoplasmic tail domain of influenza B virus hemagglutinin is important for its incorporation into virions but is not essential for virus replication in cell culture in the presence of compensatory mutations. J Virol 86:11633-11644, 2012.
  5. Shimojima M, Kawaoka Y. Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus gycoprotein. J Vet Med Sci 74:1363-1366, 2012.
  6. Shimojima M, Ströher U, Ebihara H, Feldmann H, Kawaoka Y. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J Virol 86: 2067-2078, 2012.
  7. Victor ST, Watanabe S, Katsura H, Ozawa M, Kawaoka Y. A replication-incompetent PB2-knockout influenza A virus vaccine vector. J Virol 86: 4123-4128, 2012.
  8. Nidom CA, Yamada S, Nidom RV, Rahmawati K, Alamudi MY, Kholik, Indrasari S, Hayati RS, Iwatsuki Horimoto K, Kawaoka Y. Genetic characterization of H5N1 influenza viruses isolated from chickens in Indonesia in 2010. Virus Genes 44: 459-465, 2012.
  9. Shinya K, Gao Y, Cilloniz C, Suzuki Y, Fujie M, Deng G, Zhu Q, Fan S, Makino A, Muramoto Y, Fukuyama S, Tamura D, Noda T, Eisfeld AJ, Katze MG, Chen H, Kawaoka Y. Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque. J Virol 86: 6055-6066, 2012.
  10. Kikuchi T, Iwatsuki-Horimoto K, Adachi E, Koga M, Nakamura H, Hosoya N, Kawana-Tachikawa A, Koibuchi T, Miura T, Fujii T, Kawaoka Y, Iwamoto A. Improved neutralizing antibody response in the second season after a single dose of pandemic (H1N1) 2009 influenza vaccine in HIV-1-positive adults. Vaccine 30: 3819-3823, 2012.
  11. Watanabe T, Imai M, Watanabe S, Shinya K, Hatta M, Li C, Neumann G, Ozawa M, Hanson A, Zhong G, Fukuyama S, Kawakami E, Simmons HA, Schenkman D, Brunner K, Capuano SV 3rd, Weinfurter JT, Kilander A, Dudman SG, Suresh M, Hungnes O, Friedrich TC, Kawaoka Y. Characterization in vitro and in vivo of pandemic (H1N1) 2009 viruses isolated from patients. J Virol 86: 9361-9368, 2012.
  12. Zhang Y, Zhang Q, Gao Y, He X, Kong H, Jiang Y, Guan Y, Xia X, Shu Y, Kawaoka Y, Bu Z, Chen H. Key molecular factors in HA and PB2 contribute to the efficient transmission of the 2009 H1N1 pandemic influenza virus. J Virol 86: 9666-9674, 2012.
  13. Inagaki A, Goto H, Kakugawa S, Ozawa M, Kawaoka Y. Competitive incorporation of homologous gene segments of influenza A virus into virions. J Virol 86: 10200-10202, 2012.
  14. Okame M, Adachi E, Sato H, Shimizu S, Kikuchi T, Miyazaki N, Koga M, Nakamura H, Suzuki M, Oyaizu N, Fujii T, Iwamoto A, Koibuchi T. Shigella sonnei outbreak among men who have sex with men (MSM) in Tokyo. Jpn J Infect Dis 65: 277-278, 2012.
  15. Adachi E, Koibuchi T, Imai K, Kikuchi T, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T. Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient. International Journal of STD & AIDS 23:603-605, 2012.
  16. Ishikawa H, Meng F, Kondo N, Iwamoto A, Matsuda Z. Generation of a dual-functional split-reporter protein for monitoring membrane fusion using self-associating split GFP. Protein Engineering, Design & Selection (2012) doi: 10.1093/protein/gzs051, first published online: August 30, 2012.
  17. Saito M, Kato Y, Ito E, Fujimoto J, Ishikawa K, Doi A, Kumazawa K, Matsui A, Takebe S, Ishida T, Azuma S, Mochizuki H, Kawamura Y, Yanagisawa Y, Honma R, Imai J, Ohbayashi H, Goshima N, Semba K, Watanabe S. Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene. FEBS Lett 12;586(12): 1708-1714, 2012.
  18. Kobayashi-Ishihara M, Yamagishi M, Hara T, Matsuda Y, Takahashi R, Miyake A, Nakano K, Yamochi T, Ishida T, Watanabe T. HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period. Retrovirology 9:38, 2012.
  19. Taguchi Y, Kiga Y, Gohda J, Inoue J. Identification and characterization of anti-osteoclastogenic peptides derived from the cytoplasmic tail of RANK. J Bone Miner Metab 30: 543-553, 2012.
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  23. Doronin K, Flatt JW, Di Paolo NC, Khare R, Kalyuzhniy O, Acchione M, Sumida JP, Ohto U, Shimizu T, Akashi-Takamura S, Miyake K, Macdonald JW, Bammler TK, Beyer RP, Farin FM, Stewart PL, Shayakhmetov DM. Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus. Science 338(6108): 795-798, 2012.
  24. Ohto U, Yamakawa N, Akashi-Takamura S, Miyake K, Shimizu T.  Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I. J Biol Chem, 2012 (Epub ahead of print).
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  26. Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y. The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. Diabetes 61: 1199-1209, 2012.
  27. Honda H, Nagai Y, Matsunaga T, Saitoh SI, Akashi-Takamura S, Hayashi H, Fujii I, Miyake K, Muraguchi A, Takatsu K. Cyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol 91: 967-976, 2012.
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  31. Fukui R, Miyake K. Controlling systems of nucleic acid sensing-TLRs restrict homeostatic inflammation. Exp Cell Res 318: 1461-1466, 2012.
  32. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol (2012) Jul 25 (Epub ahead of print).
  33. Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T. Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad. J Thorac Oncol 7:1872-1876, 2012. (DOI: 10.1097/JTO.0b013e3182721ed1.)
  34. Ishimura M, Sakurai-Yageta M, Maruyama T, Ando T, Fukayama M, Goto A, Murakami Y. Involvement of miR-214 and miR-375 in malignant features of non-small-cell lung cancer by down-regulating CADM1. J Cancer Therapy 3:379-387, 2012. (DOI: 10.4236/jct.2012.324050.)
  35. Ito A, Mimae T, Yamamoto Y-S-Z, Hagiyama M, Nakanishi J, Ito M, Hosokawa Y, Okada M, Murakami Y, Kondo T. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis. Lab Invest 92:1374-1385, 2012. (DOI: 10.1038/labinvest.2012.98.)
  36. Nakata H, Wakayama T, Adthapanyawanich K, Nishiuchi T, Murakami Y, Takai Y, Iseki S. Compensatory upregulation of myelin protein zero-like 2 expression in spermatogenic cells in cell adhesion molecule-1-deficient mice. Acta Histochem Cytochem 45:47-56, 2012.
  37. Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Masuda T, Tsuda H, Kanai Y, Onizuka M, Sato Y, Murakami Y. Expression of a splicing variant of the CADM1 specific to small cell lung cancer. Cancer Science 103: 1051-1057, 2012.
  38. Mimae T, Okada M, Hagiyama M, Miyata Y, Tsutani Y, Inoue T, Murakami Y, Ito A. Notch2 and Six1 are up-regulated during progression of early-stage lung adenocarcinoma and define its unfavorable subset at advanced stages. Clinical Cancer Research 18: 945-948, 2012.
  39. Nagara Y, Hagiyama M, Hatano, N, Futai, E, Suo S, Takaoka Y, Murakami Y, Ishiura S, Ito A. Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by A disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex. Biochem Biophys Res Commun 417: 462-467, 2012.
  40. Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y. Aberrant expression of tumor suppressors, CADM1 and 4.1B, in invasive lesions of primary breast cancer. Breast Cancer 19: 242-252, 2012.
  41. Nagata M, Sakurai-Yageta M, Yamada D, Goto A, Ito A, Fukuhara H, Kume H, Morikawa T, Fukayama M, Homma Y, Murakami Y. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. Int J Cancer 130: 1329-1337, 2012.
  42. Tanaka M, Kato A, Satoh Y, Ide T, Sagou K, Kimura K, Hasegawa H, Kawaguchi Y. Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence. J Virol 86: 5264-5277, 2012.

2011

  1. Das SC, Watanabe S, Hatta M, Noda T, Neumann G, Ozawa M, Kawaoka Y. The arginine residues at positions 76-78 of influenza A virus matrix protein M1 play an important role in viral replication. J Virol (2011) Nov 16 (Epub ahead of print).
  2. Murakami S, Horimoto T, Ito M, Takano R, Katsura H, Shimojima M, Kawaoka Y. Enhanced growth of influenza vaccine seed viruses in Vero cells mediated by broadening the optimal pH range for virus membrane fusion. J Virol (2011) Nov 16 (Epub ahead of print).
  3. Yamada S, Shinya K, Takada A, Ito T, Suzuki T, Suzuki Y, Le QM, Ebina M, Kasai N, Kida H, Horimoto T, Rivailler P, Chen LM, Donis RO, Kawaoka Y. Adaptation of a duck influenza A virus in quail. J Virol (2011) Nov 16 (Epub ahead of print).
  4. Ginting TE, Shinya K, Kyan Y, Makino A, Matsumoto N, Kaneda S, Kawaoka Y. Amino acid changes in hemagglutinin contribute to the replication of oseltamivir-resistant H1N1 influenza viruses. J Virol 86:121-127, (2012) Epub 2011 October 19.
  5. Watanabe T, Shinya K, Watanabe S, Imai M, Hatta M, Li C, Wolter BF, Neumann G, Hanson A, Ozawa M, Yamada S, Imai H, Sakabe S, Takano R, Iwatsuki-Horimoto K, Kiso M, Ito M, Fukuyama S, Kawakami E, Gorai T, Simmons HA, Schenkman D, Brunner K, Capuano SV 3rd, Weinfurter JT, Nishio W, Maniwa Y, Igarashi T, Makino A, Travanty EA, Wang J, Kilander A, Dudman SG, Suresh M, Mason RJ, Hungnes O, Friedrich TC, Kawaoka Y. Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques. J Virol 85:13195-13203, 2011.
  6. Octaviani CP, Goto H, Kawaoka Y. Reassortment between seasonal H1N1 and pandemic (H1N1) 2009 influenza viruses is restricted by limited compatibility among polymerase subunits. J Virol 85:8449-8452, 2011.
  7. Horimoto T, Maeda K, Murakami S, Kiso M, Iwatsuki-Horimoto K, Sashika M, Ito T, Suzuki K, Yokoyama M, Kawaoka Y. Highly pathogenic avian influenza virus infection in feral raccoons, Japan. Emerging Infectious Diseases 17:714-717, 2011.
  8. Shimizu K, Li C, Muramoto Y, Yamada S, Arikawa J, Chen H, Kawaoka Y. The NP and M segments of H5N1 influenza viruses are responsible for dominance in embryonated eggs. J Gen Virol 92:1645-1649, 2011.
  9. Kondo N, Miyauchi K, Matsuda Z. Monitoring viral-mediated membrane fusion using fluorescent reporter methods. Curr Protoc Cell Biol, Chapter 26: Unit 26.9, 2011.
  10. Shinya K, Makino A, Tanaka H, Hatta M, Watanabe T, Le MQ, Imai H, Kawaoka Y. Systemic dissemination of H5N1 influenza A viruses in ferrets and hamsters after direct intragastric inoculation. J Virol 85:4673-4678, 2011.
  11. Shinya K, Makino A, Hatta M, Watanabe S, Kim JH, Hatta Y, Gao P, Ozawa M, Le QM, Kawaoka Y. Subclinical brain injury caused by H5N1 influenza virus infection. J Virol 85:5202-5207, 2011.
  12. Shinya K, Okamura T, Sueta S, Kasai N, Tanaka M, Ginting TE, Makino A, Eisfeld AJ, Kawaoka Y. Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses. Virol J 8:97, 2011.
  13. Sakabe S, Iwatsuki-Horimoto K, Takano R, Nidom CA, Le MT, Nagamura-Inoue T, Horimoto T, Yamashita N, Kawaoka Y. Cytokine production by primary human macrophages infected with highly pathogenic H5N1 or pandemic H1N1 2009 influenza viruses. J Gen Virol 92:1428-1434, 2011.
  14. Kiso M, Ozawa M, Le MT, Imai H, Takahashi K, Kakugawa S, Noda T, Horimoto T, Kawaoka Y. Effect of an asparagine-to-serine mutation at position 294 in neuraminidase on the pathogenicity of highly pathogenic H5N1 influenza A virus. J Virol 85:4667-4672, 2011.
  15. Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y. Sero-prevalence of pandemic (H1N1) 2009 Influenza A Virus among schoolchildren and their parents in Tokyo, Japan. Clin Vaccine Immunol 18:860-866, 2011.
  16. Ozawa M, Basnet S, Burley LM, Neumann G, Hatta M, Kawaoka Y. Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses. J Virol 85:4596-5601, 2011.
  17. Tamura D, Sugaya N, Ozawa M, Takano R, Ichikawa M, Yamazaki M, Kawakami C, Shimizu H, Uehara R, Kiso M, Kawakami E, Mitamura K, Kawaoka Y. Frequency of drug-resistant viruses and virus shedding in pediatric influenza patients treated with neuraminidase inhibitors. Clin Infect Dis 52:432-7, 2011.
  18. Shinya K, Ito M, Makino A, Tanaka M, Miyake K, Eisfeld AJ, Kawaoka Y. The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection. J Virol 86:19-24, (2012) Epub 2011 Oct 26.
  19. Hatakeyama S, Iwatsuki-Horimoto K, Okamoto K, Nukui Y, Yata N, Fujita A, Inaba S, Yotsuyanagi H, Kawaoka Y. Unadjuvanted pandemic H1N1 influenza vaccine in HIV-1-infected adults. Vaccine 29(49):9224-9228, 2011.
  20. Ozawa M, Victor ST, Taft AS, Yamada S, Li C, Hatta M, Das SC, Takashita E, Kakugawa S, Maher EA, Neumann G, Kawaoka Y. Replication-incompetent influenza A viruses that stably express a foreign gene. J Gen Virol 92 (Pt 12):2879-2888, 2011.
  21. Sakabe S, Ozawa M, Takano R, Iwastuki-Horimoto K, Kawaoka Y. Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice. Virus Res 158 (1-2):124-129, 2011.
  22. Liu J, Chen P, Jiang Y, Wu L, Zeng X, Tian G, Ge J, Kawaoka Y, Bu Z, Chen H. A duck enteritis virus-vectored bivalent live vaccine provides fast and complete protection against H5N1 avian influenza virus infection in ducks. J Virol 85 (21):10989-10998, 2011.
  23. Yamaoka M, Palilingan JF, Wibisono J, Yudhawati R, Nidom RV, Alamudi MY, Ginting TE, Makino A, Nidom CA, Shinya K, Kawaoka Y. Virological surveillance of human influenza in Indonesia, October 2008-March 2010. Microbiol Immunol 55:514-517, 2011.
  24. Poetranto ED, Yamaoka M, Nastri AM, Krisna LA, Rahman MH, Wulandari L, Yudhawati R, Ginting TE, Makino A, Shinya K, Kawaoka Y. An H5N1 highly pathogenic avian influenza virus isolated from a local tree sparrow in Indonesia. Microbiol Immunol 55:666-672, 2011.
  25. Nakayama K, Nakamura H, Koga M, Koibuchi T, Fujii T, Miura T, Iwamoto A, Kawana-Tachikawa A. Imbalanced Production of Cytokines by T Cells Associates with the Activation/Exhaustion Status of Memory T Cells in Chronic HIV Type 1 Infection. AIDS Res Hum Retroviruses (2011) Sep 23 (Epub ahead of print).
  26. Shi Y, Qi J, Iwamoto A, Gao G.F. Plasticity of human CD8αα binding to peptide-HLA-A*2402. Mol Immunol 48:2198-2202, (2011) Epub 2011Jun 6.
  27. Adachi E, Koibuchi T, Okame M, Sato H, Imai K, Shimizu S, Tsurita G, Oyaizu N, Iwamoto A, Fujii T. A case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis and hepatitis. J Clin Microbiol 49:4394-4396, (2011) Epub 2011 Oct 12.
  28. Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T. Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen. J Clin Microbiol 49:3703-3706, (2011) Epub 2011 Aug 17.
  29. Long Y, Meng F, Kondo N, Iwamoto A, Matsuda Z. Conserved arginine residue in the membrane-spanning domain of HIV-1 gp41 is required for efficient membrane fusion. Protein Cell 2:369-376, 2011.
  30. Ahlenstiel C, Lim H, Cooper DA, Ishida T, Kelleher, AD, Suzuki, K. Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nuc Acid Res, published on line: November 7, 2011. doi:10.1093/nar/gkr891.
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  32. Ashida H, Ogawa M, Kim M, Mimuro H, Sasakawa C. Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol 8:36-45, (2012) Epub 2011 Dec 15.
  33. Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M, Sasakawa C. Host-pathogen interactions: Cell death and infection: A double-edged sword for host and pathogen survival. J Cell Biol 195:931-942, (2011) Epub 2011 Nov 28.
  34. Ogawa M, Sasakawa C. The role of Tecpr1 in selective autophagy as a cargo receptor. Autophagy 7:1389-1391, (2011) Epub 2011 Nov 1.
  35. Ashida H, Ogawa M, Mimuro H, Kobayashi T, Sanada T, Sasakawa C. Shigella are versatile mucosal pathogens that circumvent the host innate immune system. Curr Opin Immunol 23:448-455, (2011) Epub 2011 Jul 15.
  36. Suzuki M, Kiga K, Kersulyte D, Cok J, Hooper CC, Mimuro H, Sanada T, Suzuki S, Oyama M, Kozuka-Hata H, Kamiya S, Zou QM, Gilman RH, Berg DE, Sasakawa C. Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon. J Biol Chem 286:29964-29972, (2011) Epub 2011 Jul 8.
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  38. Ishijima N, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, Boren T, Haas R, Sasakawa C, Mimuro H. BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J Biol Chem 286:25256-25264, (2011) Epub 2011 May 19.
  39. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe 9:376-389, May 2011.
  40. Ogawa M, Yoshikawa Y, Mimuro H, Hain T, Chakraborty T, Sasakawa C. Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure. Autophagy 7:310-4, Mar (2011).
  41. Kato A, Liu Z, Minowa A, Imai T, Tanaka M, Sugimoto K, Nishiyama Y, Arii J, Kawaguchi Y. Herpes Simplex Virus 1 Protein Kinase Us3 and Major Tegument Protein UL47 Reciprocally Regulate Their Subcellular Localization in Infected Cells. J Virol 85:9599-9613, (2011) Epub 2011 Jul 6.
  42. Imai T, Arii J, Minowa A, Kakimoto A, Koyanagi N, Kato A, Kawaguchi Y. Role of the Herpes Simplex Virus 1 Us3 Kinase Phosphorylation Site and Endocytosis Motifs in Envelope Glycoprotein B in Its Intracellular Transport and Neurovirulence. J Virol 85:5003-5015, (2011) Epub 2011 Mar 9.
  43. Toda T, Kuwahara K, Kondo N, Matsuda Z, Maeda Y, Maeda K, Sakaguchi N. Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4. Immunobiology 217(9): 864-872, 2012.
  44. Yang W, Ding X, Deng J, Lu Y, Matsuda Z, Thiel A, Chen J, Deng H, Qin Z. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection. J Mol Med (Berl) 89:399-409, 2011.
  45. Shi G, Yagyu F, Shimizu Y, Shimizu K, Oshima M, Iwamoto A, Gao B, Liu W, Gao GF, Kitamura Y. Flow cytometric assay using two fluorescent proteins for the function of the internal ribosome entry site of hepatitis C virus. Cytometry A 79:653-60, 2011.
  46. Tsai HJ, Kobayashi S, Izawa K, Ishida T, Watanabe T, Umezawa K, Lin SF, Tojo A. Bioimaging analysis of nuclear factor-κB activity in Philadelphia chromosome-positive acute lymphoblastic leukemia cells reveals its synergistic upregulation by tumor necrosis factor-α-stimulated changes to the microenvironment. Cancer Sci 102:2014-21, 2011.
  47. Yamamoto K, Ishida T, Nakano K, Yamagishi M, Yamochi T, Tanaka Y, Furukawa Y, Nakamura Y, Watanabe T. SMYD3 interacts with HTLV-1 Tax and regulates subcellular localization of Tax. Cancer Sci 102:260-6, 2011.
  48. Kanemaru Y, Momiki Y, Matsuura S, Horikawa T, Gohda J, Inoue J, Okamoto Y, Fujita F, Otsuka M. An artificial copper complex incorporating a cell-penetrating peptide inhibits NF-kB activation. Chem Pharm Bull 59:1555-8, 2011.
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2010

  1. Song J, Feng H, Xu J, Zhao D, Shi J, Li Y, Deng G, Jiang Y, Li X, Zhu P, Guan Y, Bu Z, Kawaoka Y, and Chen H. The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. J Virol 85:2180-2188, (2011) Epub 2010 Dec 22.
  2. Yu M, Liu X, Sun L, Chen C, Ma G, Kitamura Y, Gao GF, and Liu W. Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein. Virus Res 152:104-114, 2010.
  3. Song XH, Xiao H, Huang Y, Fu G, Jiang B, Kitamura Y, Liu W, Liu D, and Gao GF. Serological surveillance of influenza A virus infection in swine populations in Fujian province, China: no evidence of naturally occurring H5N1 infection in pigs. Zoonoses Public Health 57:291-298, 2010.
  4. Sun Y, Liu J, Yang M, Gao F, Zhou J, Kitamura Y, Gao B, Tien P, Shu Y, Iwamoto A, Chen Z, and Gao GF. Identification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from the H5N1 subtype of influenza A viruses. J Gen Virol 91:919-930, 2010.
  5. Kondo N, Miyauchi K, Meng F, Iwamoto A, and Matsuda Z. Conformational changes of the HIV-1 envelope protein during membrane fusion are inhibited by the replacement of its membrane-spanning domain. J Biol Chem 285:14681-14688, 2010.
  6. Nidom CA, Takano R, Yamada S, Sakai-Tagawa Y, Daulay S, Aswadi D, Suzuki T, Suzuki Y, Shinya K, Iwatsuki-Horimoto K, Muramoto Y, and Kawaoka Y. H5N1 influenza viruses from pigs in Indonesia. Emerg Inf Dis 16:1515-1523, 2010.
  7. Chen Y, Zhong G, Wang G, Deng G, Li Y, Shi J, Zhang Z, Guan Y, Jiang Y, Bu Z, Kawaoka Y, and Chen H. Dogs are highly susceptible to H5N1 avian influenza virus. Virology 405:15-19, 2010.
  8. Le QM, Ito M, Muramoto Y, Hoang PV, Vuong CD, Sakai-Tagawa Y, Kiso M, Ozawa M, Takano R, and Kawaoka Y. Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans from 2003 to 2008 in Northern Vietnam. J Gen Virol 91:2485-2490, 2010.
  9. Sakabe S, Iwatsuki-Horimoto K, Horimoto T, Nidom CA, Le MQ, Takano R, Kubota-Koketsu R, Okuno Y, Ozawa M, and Kawaoka Y. A cross-reactive neutralizing monoclonal antibody protects mice from H5N1 and pandemic (H1N1) 2009 virus infection. Antiviral Res 88:249-55, (2010) Epub 2010 Sep 16.
  10. Hatta Y, Hershberger K, Shinya K, Dubielzig RR, Hatta M, Kawaoka Y, and Suresh M. Viral replication rate regulates clinical outcome and CD8 T cell responses during highly pathogenic H5N1 influenza virus infection in mice. PLoS Pathog 6:e1001139, 2010.
  11. Imai H, Shinya K, Takano R, Kiso M, Muramoto Y, Sakabe S, Murakami S, Ito M, Yamada S, Le MQ, Nidom CA, Sakai-Tagawa Y, Takahashi K, Omori Y, NodaT, Shimojima M, Kakugawa S, Goto H, Iwatsuki-Horimoto K, Horimoto T, and Kawaoka Y. The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets. PLoS Pathog 6:e1001106, 2010.
  12. Octaviani CP, Ozawa M, Yamada S, Goto H, and Kawaoka Y. High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. J Virol 84:10918-10922, 2010.
  13. Yamada S, Hatta M, Staker BL, Watanabe S, Imai M, Shinya K, Sakai-Tagawa Y, Ito M, Ozawa M, Watanabe T, Sakabe S, Li C, Kim JH, Myler PJ, Phan I, Raymond A, Smith E, Stacy R, Nidom CA, Lank SM, Wiseman RW, Bimber BN, O’Connor DH, Neumann G, Stewart LJ, and Kawaoka Y. Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog 6:e1001034, 2010.
  14. Sakai-Tagawa Y, Ozawa M, Tamura D, Le QM, Nidom CA, Sugaya N, and Kawaoka Y. Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses. J Clin Microbiol 48:2872-2877, 2010.
  15. Kiso M, Kubo S, Ozawa M, Le QM, Nidom CA, Yamashita M, and Kawaoka Y. Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses. PLoS Pathog 6:e21000786, 2010.
  16. Shinya K, Makino A, Hatta M, Watanabe S, Kim JH, and Kawaoka Y. A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage. J Gen Virol 91:1461-1463, 2010.
  17. Kiso M, Takahashi K, Sakai-Tagawa Y, Shinya K, Sakabe S, Le QM, Ozawa M, Furuta Y, and Kawaoka Y. T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc Natl Acad Sci USA 107:882-887, 2010.
  18. Miyauchi K, Curran AR, Long Y, Kondo N, Iwamoto A, Engelman DM, and Matsuda Z. The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology 7:95, 2010.
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  21. Yu L, Aoki C, Shimizu Y, Shimizu K, Hou W, Yagyu F, Wen X, Oshima M, Iwamoto A, Gao B, Liu W, Gao GF, and Kitamura Y. Development of a simple system for screening anti-hepatitis C virus drugs utilizing mutants capable of vigorous replication. J Virol Methods 169:380-384, (2010) Epub 2010 Aug 14.
  22. Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sasakawa C. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response. Nat Cell Biol 12:66-73, (2010) Epub 2009 Dec 13.
  23. Kiso M, Shinya K, Shimojima M, Takano R, Takahashi K, Katsura H, Kakugawa S, Le MT, Yamashita M, Furuta Y, Ozawa M, Kawaoka Y. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoS Pathog 6:e1001079, 2010
  24. Grandea AG 3rd, Olsen OA, Cox TC, Renshaw M, Hammond PW, Chan-Hui PY, Mitcham JL, Cieplak W, Stewart SM, Grantham ML, Pekosz A, Kiso M, Shinya K, Hatta M, Kawaoka Y, Moyle M. Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses. Proc Natl Acad Sci U S A 107:12658-12663, (2010) Epub 2010 Jul 1.
  25. Monteerarat Y, Sakabe S, Ngamurulert S, Srichatraphimuk S, Jiamtom W, Chaichuen K, Thitithanyanont A, Permpikul P, Songserm T, Puthavathana P, Nidom CA, Mai le Q, Iwatsuki-Horimoto K, Kawaoka Y, Auewarakul P. Induction of TNF-alpha in human macrophages by avian and human influenza viruses. Arch Virol 155:1273-1279, (2010) Epub 2010 Jun 9.
  26. Li C, Hatta M, Nidom CA, Muramoto Y, Watanabe S, Neumann G, and Kawaoka Y. Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci USA 107:4687-4692, 2010.
  27. Sun Y, Liu J, Yang M, Gao F, Zhou J, Kitamura Y, Gao B, Tien P, Shu Y, Iwamoto A, Chen Z, Gao GF. Identification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from the H5N1 subtype of influenza A viruses. J Gen Virol 91:919-930, (2010) Epub 2009 Dec 2.
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  31. Ashida H, Ogawa M, Kim M, Suzuki S, Sanada T, Punginelli C, Mimuro H, Sasakawa C. Shigella deploy multiple countermeasures against host innate immune responses. Curr Opin Microbiol 14:16-23, (2011) Epub 2010 Oct 8.
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  34. Arii J, Goto H, Suenaga T, Oyama M, Kozuka-Hata H, Imai T, Minowa A, Akashi H, Arase H, Kawaoka Y, Kawaguchi Y. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus 1. Nature 467:859-862, 2010.
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